Short answer- yes. I'm not much of a Pokemon fan (the card game, cartoon show, etc), but I enjoyed the original GB game and don't see why they shouldn't attempt to modernize the games. It'd be neat to see a 3d, explorable world with beautiful graphics.
Although I agree with Tanooki and others, I'd just like to see good graphics in a 3d world with fully animated characters, which doesn't necessarily mean Skyrim-like.
If you haven't seen any gameplay from Ni No Kuni, check this out-
I think Pokeman fans would go nuts if there was a new game that looked anything like that.
But you can argue that it's very unrealistic to expect Nintendo to put in the effort like Level 5 and Studio Ghibli.